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| Morphological mimicry and molecular interactions determine
affinities in nature and drug target interactions in pharmacology.
Below a wasp seduced by shape and pheromones tries to
copulate with the orchid Ophrys insectifera,
which mimics its mating partner (Foto taken by Leopold
Flohé near Tübingen, Germany, in 1971). |
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Functional and structural analysis of enzymes (above)
paves the way for the rational design of drugs. Here tryparedoxin,
a validated drug target of pathogenic trypanosomes, was
reacted with a pseudo substrate to mimic the molecular
interactions in a catalytic intermediate. (Hofmann et
al., Biol. Chem. 382, 459, 2001). |
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